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Chickenpox: An update
Coralie Lo Presti1, Christophe Curti2, Marc Montana1
1Assistance publique-Hôpitaux de Marseille (AP-HM), pharmacie usage intérieur, hôpital Nord, Chemin-des-Bourrely, 13915 Marseille cedex 20, France; Laboratoire de pharmaco-chimie radicalaire, faculté de pharmacie, Aix-Marseille Université, CNRS, ICR, UMR 7273, 27, boulevard Jean-Moulin-CS30064, 13385 Marseille cedex 05, France.
Chickenpox vaccination is effective, reducing incidence and creating herd immunity. Routine immunization, even with a combined vaccine, offers benefits and potential cost savings, despite rare side effects.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- Chickenpox (varicella) can cause severe complications and death, especially in high-risk groups.
- VariZIG® is an alternative for unvaccinated, seronegative individuals exposed to varicella.
- Routine vaccination demonstrates efficacy in reducing chickenpox incidence and promoting herd immunity.
Purpose of the Study:
- To evaluate the impact and benefits of routine chickenpox vaccination.
- To discuss vaccination strategies, including combined vaccines and antibody titer maintenance.
- To assess the economic implications of chickenpox in France.
Main Methods:
- Review of existing data on chickenpox incidence and vaccination efficacy.
- Analysis of antibody titers in vaccinated individuals over time.
- Consideration of the tolerability and side effects of available vaccines.
- Economic evaluation of direct and indirect costs associated with chickenpox.
Main Results:
- Vaccination significantly decreases chickenpox incidence and establishes herd immunity.
- Antibody titers wane over time but can be boosted with a second vaccine dose.
- A tetravalent measles-mumps-rubella-chickenpox vaccine shows good tolerability, with rare fever and febrile seizures.
- Routine vaccination can lead to cost savings by reducing chickenpox-related expenses.
Conclusions:
- Routine chickenpox vaccination is a beneficial public health strategy.
- Maintaining antibody titers through vaccination schedules is important for long-term protection.
- Implementing vaccination programs, including combined vaccines, can improve health outcomes and reduce economic burdens associated with chickenpox.
