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A systematic understanding of signaling by ErbB2 in cancer using phosphoproteomics

C Sidhanth1,1, P Manasa1,1, S Krishnapriya1,1

  • 1Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), 38 Sardar Patel Road Guindy, Chennai-600036, India.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|May 25, 2018
PubMed

Insights

This review analyzes ErbB2 signaling pathways and phosphoproteome analysis techniques. Identifying new phosphoproteins can reveal therapeutic targets and markers for ErbB2-inhibiting compounds.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • ErbB2 is a receptor tyrosine kinase crucial for cellular functions like proliferation.
  • ErbB2 amplification is common in breast and gastric cancers, making it a therapeutic target.
  • Trastuzumab is an effective therapeutic antibody for ErbB2-amplified cancers.

Purpose of the Study:

  • To critically analyze published data on ErbB2 signaling pathways and interacting proteins.
  • To review techniques for evaluating the phosphoproteome after ErbB2 activation.
  • To highlight the potential of phosphoproteins as therapeutic targets and surrogate markers.

Main Methods:

  • Literature review of signaling pathways and protein interactions.
  • Analysis of phosphoproteomic evaluation techniques.
  • Discussion of therapeutic implications.

Main Results:

  • ErbB2 signals downstream via heterodimerization, independent of a specific ligand.
  • Phosphoproteomic analysis can identify novel therapeutic targets and markers.
  • Understanding ErbB2 signaling is key to developing targeted therapies.

Conclusions:

  • Comprehensive analysis of ErbB2 signaling pathways and phosphoproteome is essential.
  • New phosphoproteins identified can serve as biomarkers and therapeutic targets.
  • Improved understanding of ErbB2 signaling will advance cancer treatment.
Keywords:
EGFErbB2canceregfphosphoproteinphosphoprotéinesignalingsignalisation

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