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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Bacterial regulatory RNAs: complexity, function, and putative drug targeting.

Hong-Leong Cheah1, Carsten A Raabe2,3,4, Li-Pin Lee1

  • 1a Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia , Kepala Batas , Malaysia.

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Summary
This summary is machine-generated.

Regulatory bacterial non-protein coding RNAs (npcRNAs) are crucial for gene expression and bacterial adaptability. Understanding their mechanisms may lead to novel antibiotic development.

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Bacterial non-protein coding RNAscis- and trans-antisense transcriptionregulation of gene expression

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Recent advances in RNA-deep sequencing have revealed numerous non-protein coding RNAs (npcRNAs) in bacteria.
  • These npcRNAs play critical roles in regulating gene expression, influencing essential bacterial processes.

Purpose of the Study:

  • To comprehensively review the mechanisms of gene expression regulated by bacterial npcRNAs.
  • To highlight the potential of these regulatory molecules as targets for new antibiotic development.

Main Methods:

  • Review of existing literature on bacterial npcRNAs and their functions.
  • Analysis of characterized examples of regulatory npcRNAs and their mechanisms of action.

Main Results:

  • Bacterial npcRNAs regulate gene expression through diverse mechanisms, including transcriptional termination, translation modulation, mRNA stability alteration, and protein sequestration.
  • These regulatory RNAs contribute significantly to bacterial adaptability, environmental stress responses, virulence, and antibiotic resistance.

Conclusions:

  • Regulatory bacterial npcRNAs are key determinants of bacterial adaptability and function in various contexts.
  • The intricate mechanisms of these npcRNAs present promising avenues for the development of novel antimicrobial strategies.