Related Experiment Video

Updated: Feb 10, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

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Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography

Zhixin Jiang1, Haipeng Tang2, Jianzhou Shi1

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Nuclear Medicine Communications
|May 26, 2018
PubMed

Insights

Myocardial stunning worsens left ventricular mechanical dyssynchrony (LVMD) during stress compared to rest. These LVMD changes may help diagnose coronary artery disease (CAD).

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Myocardial stunning is a nonperfusion marker for coronary artery disease (CAD), particularly severe multivessel CAD.
  • Assessing left ventricular mechanical dyssynchrony (LVMD) is crucial for evaluating cardiac function.

Purpose of the Study:

  • To evaluate how myocardial stunning influences LVMD parameters between stress and rest conditions.
  • To determine the diagnostic value of LVMD changes in patients with suspected or known CAD.

Main Methods:

  • Retrospective analysis of 113 patients undergoing stress/rest Tc-sestamibi gated SPECT MPI.
  • Myocardial stunning defined as ischemia and wall dysfunction in the same coronary territory.
  • Comparison of LVMD parameters (phase SD, histogram bandwidth) between stunning and non-stunning groups.

Main Results:

  • No significant LVMD changes between stress and rest in the non-stunning group.
  • In the stunning group, phase SD and histogram bandwidth for both contraction and relaxation were significantly higher during stress than rest (P<0.05).

Conclusions:

  • Myocardial stunning leads to deterioration in both systolic and diastolic LVMD parameters.
  • LVMD parameter changes associated with myocardial stunning may offer incremental value in diagnosing CAD.
Abstract

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