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Molecular Evolution of the Tre Recombinase
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Molecular Evolution in a Peptide-Vesicle System.

Christian Mayer1, Ulrich Schreiber2, María J Dávila3

  • 1Institute of Physical Chemistry, CENIDE, University of Duisburg-Essen, 45141 Essen, Germany. christian.mayer@uni-due.de.

Life (Basel, Switzerland)
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Researchers propose a new model for the origin of life, demonstrating a stable system of self-reproducing vesicles and peptides. This system shows potential for molecular evolution and developing new functions, mimicking early life processes.

Keywords:
evolutionmolecular evolutionorigin of lifepeptidesprebiotic chemistryvesicles

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Area of Science:

  • Origin of Life Studies
  • Biochemistry
  • Systems Chemistry

Background:

  • Understanding the origin of life requires models that explain the emergence of self-sustaining, evolving systems.
  • Early life likely involved the interplay of structural components (like vesicles) and functional molecules (like peptides).

Purpose of the Study:

  • To propose and demonstrate a novel model for the origin of life based on interacting cyclic processes.
  • To investigate a system capable of structural reproduction, self-optimization, and molecular evolution under realistic conditions.

Main Methods:

  • Integration of two cyclic processes: one providing vesicles, the other supplying peptides from diverse amino acids.
  • Utilizing liquid chromatography combined with high-resolution mass spectrometry to identify vesicle-interacting peptides.
  • Experimental analysis of vesicle-peptide interactions and their effects on vesicle properties.

Main Results:

  • Demonstrated a stable system with mutual stabilization between vesicles and peptides.
  • Observed vesicle-induced accumulation and selection of specific membrane-interacting peptides.
  • Identified immediate effects of selected peptides on vesicles, including reduced size, increased permeability, and enhanced thermal stability.

Conclusions:

  • The proposed system models key principles of life, including self-existence, evolution, and development of novel functions.
  • This model offers a potential pathway for the formation of self-evolving structures leading to the first living cell.
  • Experimental evidence supports the crucial role of vesicle-peptide co-evolution in early life emergence.