Mixed-scale poly(methyl methacrylate) channel network-based single-particle manipulation via diffusiophoresis

Area of Science:

• Microfluidics
• Nanotechnology
• Materials Science

Background:

• Nanochannel fabrication is challenging and costly.
• Integrating micro- and nano-scale channels is crucial for fluidic devices.
• Existing methods lack affordability and versatility.

Purpose of the Study:

• To develop a simple, cost-effective fabrication method for mixed-scale channel networks.
• To enable efficient sample transport and particle manipulation in nanochannels.
• To demonstrate a novel diffusiophoresis-based single-particle entrapment technique.

Main Methods:

• Hot-embossing of poly(methyl methacrylate) (PMMA) using a batch-fabricated carbon stamp.
• Integration of microchannels with nanochannels via 3D microfunnels.
• Utilizing solute gradients for diffusiophoresis-based particle entrapment.

Main Results:

• Successful fabrication of collapse-free, mixed-scale channels using PMMA and a carbon stamp.
• 3D microfunnels facilitate smooth sample transport and act as single-particle entrapment chambers.
• Demonstrated controllable, equipment-free particle manipulation via diffusiophoresis.

Conclusions:

• The developed method offers an affordable and versatile approach to nanochannel fabrication.
• Diffusiophoresis-based particle entrapment in microfluidic devices is achieved for the first time.
• This technique has potential applications in particle manipulation and analysis.