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Updated: Feb 10, 2026

Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Preventive Effects of Oxidized Dextran on Functional Activity of Pulmonary Macrophages in Mice Infected with
O V Potapova1, L A Cherdantseva2, A V Kovner3
1Optimum Medical Laboratory, Research-and-Educational Center, Sochi, Russia.
Abstract:
We analyzed cytokine profile of pulmonary macrophages in mice infected with highly pathogenic influenza A/H5N1 virus after preventive injections of oxidized dextran. Light microscopy, immunohistochemistry, and morphometric examinations showed that preventive injections of oxidized dextran led to more effective virus elimination, modulation of the proinflammatory cytokine response, and host antiviral response and reduce animal mortality. Our findings allow recommending oxidized dextran for further studies in order to create a vaccine with antiviral and adjuvant potencies.
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