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Role of JAK/STAT3 Signaling in Functional Stimulation of Mesenchymal Progenitor Cells by Fibroblast Growth Factor

G N Zyuz'kov1,2, E V Udut3, L A Miroshnichenko3

  • 1E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia. zgn@pharmso.ru.

Bulletin of Experimental Biology and Medicine
|May 26, 2018
PubMed

Insights

Fibroblast growth factor activates JAK/STAT signaling in progenitor cells. JAKs and STAT3 stimulate cell proliferation and control maturation, with distinct roles in differentiation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Stem Cell Research

Background:

  • The JAK/STAT signaling pathway plays a crucial role in cellular processes.
  • Mesenchymal progenitor cells possess proliferation and differentiation potential.
  • Fibroblast growth factor is a key regulator of cell behavior.

Purpose of the Study:

  • To investigate the role of the JAK/STAT pathway in mesenchymal progenitor cell function.
  • To elucidate the specific contributions of JAKs and STAT3 to proliferation and differentiation.
  • To understand the effects of JAK and STAT3 inhibition on CFU-fibroblast activity.

Main Methods:

  • Functional stimulation of mesenchymal progenitor cells with fibroblast growth factor.
  • Pharmacological blockade of Janus kinases (JAKs).
  • Selective inactivation of Signal Transducer and Activator of Transcription 3 (STAT3).

Main Results:

  • JAKs and STAT3 exhibit stimulating effects on progenitor cell mitotic activity.
  • JAK blockade reduced fibroblast colony formation and proliferation while increasing differentiation.
  • STAT3 inhibition led to a coordinated decrease in proliferation and differentiation parameters.

Conclusions:

  • JAKs and STAT3 are essential regulators of mesenchymal progenitor cell proliferation and differentiation.
  • Distinct roles for JAKs and STAT3 in controlling progenitor cell maturation were identified.
  • Targeting JAK/STAT signaling offers potential for modulating stem cell behavior.
Keywords:
JAK/STAT signalingfibroblast growth factorprogenitor cellsregenerative medicinesignal transduction

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