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Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia
Yu S Kisrieva1, N A Petushkova2, N F Samenkova2
1V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. juliaks@bk.ru.
Abstract:
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
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