Related Experiment Video
Updated: Feb 10, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
[The clinicopathological associations between TGF-β1 and papillary thyroid carcinoma: a Meta-analysis.]
1School of Clinical Medicine, Jining Medical University, Jining,272067,China.
Abstract:
Objective:To comprehensively evaluate the association between the positive expression rate of transforming growth factor beta 1 (TGF-β1) and papillary thyroid carcinoma (PTC) by using Meta-analysis.Method:Search the CNKI, Wan fang, VIP and PubMed database for accumulating papers studying on the relationship between the positive expression of TGF-β1 and PTC in Chinese and English. Revman 5.3 was used to analyze the included trials.Result:A total of 6 studies comprising 617 samples was included in the meta-analysis. The TGF-β1 were found in 243 patients (64.63%) of 376 PTC patients, and the total positive expression rate is 46.19%. Performing the subgroup analysis according to age, gender, lymphatic metastasis and TNM, the results showed that there was a significant association between the positive expression rate of TGF-β1 and lymphatic metastasis (OR=5.44, 95%CI3.31-8.93,P <0.000 01).Conclusion:This meta-analysis confirmed significant associations between the expression of TGF-β1 and PTC with lymph node metastasis. TGF-β1 may be used as a predictive factor for prognosis of PTC with lymph node metastasis.
Related Concept Videos
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
TGF - β Signaling Pathway
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Directing Effect of Substituents: meta-Directing Groups
Associative Learning
Classical conditioning, also known...
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

