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Updated: Feb 10, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
α,β-Unsaturated N-Acylindoles: An Alternative Class of Michael Acceptors and Their Application in Asymmetric
Quanbin Jiang1, Tenglong Guo1, Runli Gao2
1Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road , Dalian 116023 , People's Republic of China.
Abstract:
Copper(I)-catalyzed enantioselective borylation of α,β-unsaturated N-acylindoles as well as N-acylpyrroles was efficiently achieved by means of bis(pinacolato)diboron (B2pin2), affording the enantioenriched products in excellent yields with up to 99% ee. The present work provides an alternative class of Michael acceptors, that is, α,β-unsaturated N-acylindoles, for potential asymmetric transformations.
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