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Updated: Feb 10, 2026

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents
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The Long Road to Making Muscle In Vitro

Olivier Pourquié1, Ziad Al Tanoury1, Jérome Chal1

  • 1Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Harvard Stem Cell Institute, Boston, MA, United States.

Current Topics in Developmental Biology
|May 27, 2018
PubMed
Summary

Generating skeletal muscle cells in vitro from pluripotent cells (PC) is challenging. Recent methods activate Wnt signaling to create neuromesodermal progenitors, enabling skeletal muscle development for disease modeling and cell therapy.

Keywords:
MuscleNeuromesodermal progenitorsSatellite cellsWntiPS

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