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Updated: Feb 10, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
A Scientific Renaissance: Novel Drugs in Sickle Cell Disease
Ahmar U Zaidi1, Matthew M Heeney2
1Children's Hospital of Michigan, Wayne State University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, 3901 Beaubien, Detroit, MI 48201, USA.
Abstract:
We have entered an era of exploding interest in therapeutics for sickle cell disease. The expansion in our understanding of sickle cell disease pathophysiology has enhanced the range of potential therapeutic targets. From induction of fetal hemoglobin to antiadhesion molecules, we are potentially on the cusp of making life-altering modifications for individuals with sickle cell disease. This disease population cannot afford to let the current momentum wane. Studies exploring combinations of therapies affecting multiple steps in the pathophysiology and exploring novel and clinically relevant outcomes are incumbent.
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