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Related Concept Videos

pre-mRNA Processing02:01

pre-mRNA Processing

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

Pre-mRNA Processing: Modification of pre-mRNA Ends

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
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Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
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Pre-mRNA Processing: RNA Splicing01:36

Pre-mRNA Processing: RNA Splicing

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Tracheostomy Care I: Pre-procedural Steps01:16

Tracheostomy Care I: Pre-procedural Steps

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A tracheostomy is a surgical technique that involves making an incision in the neck to provide access to the trachea. It is frequently used in medical conditions such as airway obstruction and prolonged mechanical ventilation. Effective nursing management is crucial for the long-term success of a tracheostomy.
Required Equipment
The equipment necessary for tracheostomy care includes:
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Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

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Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
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The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
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[PRE-ECLAMPSIA: A NEW TEST FOR AN OLD DISEASE].

Ran Svirsky1, Noa Feldman1, Orna Levinsohn-Tavor1

  • 1Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, affiliated with the Tel-Aviv University, Sackler Faculty of Medicine, Zerifin, Israel.

Harefuah
|May 28, 2018
PubMed
Summary
This summary is machine-generated.

New algorithms can now predict pre-eclampsia in early pregnancy using maternal factors and placental angiogenic markers. This early detection may allow for preventive measures, improving maternal and fetal outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia affects 3-5% of pregnancies, causing significant maternal and fetal harm.
  • Current risk factor identification for pre-eclampsia is limited, identifying only 30% of affected women.
  • Delivery remains the only treatment for diagnosed pre-eclampsia.

Purpose of the Study:

  • To introduce novel first-trimester algorithms for predicting pre-eclampsia.
  • To highlight the potential for early detection and prevention of pre-eclampsia.

Main Methods:

  • Utilizing algorithms that incorporate maternal history, demographics, and biochemical markers.
  • Incorporating measurements such as mean arterial pressure, uterine artery flow, Placental growth factor (PLGF), Pregnancy-associated plasma protein-A (PAPP-A), and Pregnancy-specific protein-13 (PP-13).

Main Results:

  • Developed new first-trimester algorithms for pre-eclampsia prediction.
  • Identified imbalanced placental angiogenic factors and altered uterine artery flow in women who develop pre-eclampsia.

Conclusions:

  • Early detection of high-risk pregnancies for pre-eclampsia is becoming feasible.
  • Preventive strategies like low-dose aspirin and calcium may reduce pre-eclampsia incidence or severity.
  • These advancements signal a new era in pre-eclampsia detection and prevention.