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Features of Cytokine Profile in Different Age Groups
Alikhan Shortanbayev1, Beibitgul Bizhigitova1, Anel Tarabayeva1
1Department of General Immunology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Central Asian Journal of Global Health
|May 29, 2018
Summary
Cytokine levels change with age, with increased TNF-α and IL-1β, and decreased IL-2. These immune shifts in older adults highlight age-related immune status deviations.
Area of Science:
- Immunology
- Gerontology
- Biochemistry
Background:
- Age-related immune status changes correlate with disease onset.
- Cytokine profiles in the elderly offer insights into disease pathogenesis and therapeutic strategies.
- Understanding these changes can improve the quality of life for older adults.
Purpose of the Study:
- To investigate age-related changes in cytokine concentrations.
- To examine the levels of specific cytokines (IL-1β, IL-2, TNF-α, IFN-γ) in older adults.
Main Methods:
- Study included 268 participants aged 45-80 years and older.
- Participants were categorized into 8 distinct age groups.
- Concentrations of IL-1β, IL-2, TNF-α, and IFN-γ were measured.
Main Results:
- Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-1 beta (IL-1β) concentrations significantly increased with age.
- Interleukin-2 (IL-2) levels gradually decreased with age, linked to reduced T-lymphocytes.
- Interferon-gamma (IFN-γ) levels showed a gradual increase in older adults.
Conclusions:
- Significant deviations in immune parameters, specifically cytokine concentrations, were observed in older adults compared to middle-aged individuals.
- These findings underscore the dynamic nature of the immune system during aging.
- The study highlights potential biomarkers for age-related immune changes.
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