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A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding

Ashleigh Blane1, Heini W Dirr1, Sylvia Fanucchi2

  • 1Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, 2050, South Africa.

The Protein Journal
|May 31, 2018
PubMed
Summary

Phosphorylation of Ser557 in the FOXP2 forkhead domain (FHD) disrupts DNA binding. This suggests a regulatory role for phosphorylation in FOXP2-mediated transcription control.

Keywords:
DNA bindingFOXP2Forkhead boxPhosphorylationPost translational modificationTranscription regulation

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