Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study
Haomin Luo1,2, Hongli Yang2, Stuart K Gardiner3
1Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, P.R. China.
Investigative Ophthalmology & Visual Science
|May 31, 2018
Summary
Central laminar depth (LD) varies by ethnicity, age, sex, and ocular factors. African descent eyes had deeper LD, with less influence from age, axial length, and sex when measured relative to the anterior scleral canal opening (ASCO).
Area of Science:
- Ophthalmology
- Optometry
- Anatomy
Background:
- Central laminar depth (LD) is a key parameter in optic nerve head (ONH) analysis.
- Understanding factors influencing LD is crucial for diagnosing and monitoring glaucoma.
Purpose of the Study:
- To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants.
Main Methods:
- 362 healthy subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the ONH.
- Central LD was measured relative to four reference planes: Bruch's membrane opening (BMO), anterior scleral canal opening (ASCO), Bruch's membrane (BM), and sclera.
- Effects of age, sex, ethnicity, intraocular pressure (IOP), BMO area, ASCO area, and axial length on LD were assessed.
Main Results:
- Laminar visibility was most consistent within the central ASCO.
- LD relative to BMO and BM was shallower in older individuals, those with larger BMO area, longer axial length, and females.
- LD relative to ASCO was shallower in individuals with larger ASCO area, longer axial length, and in European and Hispanic vs. African descent eyes.
Conclusions:
- Central LD was deeper in African descent eyes and less influenced by age, axial length, and sex when measured relative to ASCO and sclera.
- The magnitude of these effects was small, and their clinical significance for glaucoma detection and progression requires further investigation.
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