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The antimalarial pipeline.

Rob Hooft van Huijsduijnen¹, Timothy Nc Wells¹

¹Medicines for Malaria Venture, 20 route de Pre-Bois, 1215 Geneva, Switzerland.

Current Opinion in Pharmacology

|June 4, 2018

Summary

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New high-throughput screening has identified promising malaria drug candidates. Research defines optimal profiles for antimalarials targeting various malaria stages and transmission, considering drug resistance.

Area of Science:

Drug discovery and development
Parasitology
Medicinal chemistry

Background:

Significant advancements in high-throughput phenotypic assays for malaria parasites have occurred over the last decade.
Millions of compounds have been screened using these advanced assays.
Older chemical scaffolds have been improved, and compounds optimized against known and novel drug targets.

Purpose of the Study:

To report on the discovery of new antimalarial drug candidates.
To define optimal target compound and product profiles for new antimalarials.
To address the challenge of combining new antimalarial molecules with existing ones in the context of drug resistance.

Main Methods:

Development of high-throughput phenotypic assays for malaria parasites.

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Screening of millions of chemical compounds.

Optimization of chemical scaffolds and compounds against drug targets.

Evaluation of drug candidates in clinical trials.

Main Results:

Discovery of new pipeline drug candidates for malaria treatment.
Identification of promising compounds currently in clinical trials.
Better definition of optimal profiles for antimalarials targeting different disease aspects (treatment, chemoprevention, transmission).

Conclusions:

Recent efforts have yielded significant progress in identifying new antimalarial drug candidates.
Understanding of optimal antimalarial profiles has improved, encompassing various therapeutic needs.
Strategic combination of new and existing antimalarials is crucial for managing drug resistance.