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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Systemic Predictors of Eosinophilic Chronic Rhinosinusitis
Jacqueline Ho1,2, Aneeza W Hamizan1,3, Raquel Alvarado1
11 Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, Australia.
American Journal of Rhinology & Allergy
|June 5, 2018
Summary
Eosinophilic chronic rhinosinusitis (eCRS) is linked to elevated blood eosinophils and lower ESR. Blood eosinophil counts over 0.24×10^9/L or 4.27% of white cell count predict eCRS.
Area of Science:
- Otolaryngology
- Immunology
- Allergy
Background:
- Eosinophilic chronic rhinosinusitis (eCRS) is associated with T-helper 2 or immunoglobulin E (IgE)-mediated allergic responses.
- eCRS diagnosis, prognosis, and management differ from non-eCRS.
- Understanding eCRS biomarkers is crucial for accurate diagnosis and treatment.
Purpose of the Study:
- To investigate the association between biomarkers and eCRS.
- To identify predictors of eCRS in adult patients.
Main Methods:
- A cross-sectional study of 345 adult patients with chronic rhinosinusitis (CRS) undergoing endoscopic sinus surgery.
- eCRS defined by histopathology (>10 eosinophils/high-power field).
- Preoperative blood tests included full blood count (eosinophils, white cell count - WCC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and serum-specific IgE (ImmunoCAP).
Main Results:
- 206 patients (59.7%) had eCRS; 41% had asthma and 47% had CRS with nasal polyps.
- eCRS patients showed significantly elevated blood eosinophils (0.42±0.34 vs 0.17±0.13×10^9/L) and eosinophil ratio (6.21±4.48 vs 2.55±1.84%).
- Lower ESR was observed in eCRS patients (8.1±7.87 vs 10.65±11.91). Blood eosinophil levels >0.24×10^9/L predicted high tissue eosinophilia (AUC: 0.792).
Conclusions:
- eCRS is characterized by elevated blood eosinophils and eosinophil ratios.
- Lower ESR is also associated with eCRS.
- Blood eosinophil counts >0.24×10^9/L or >4.27% of WCC are significant predictors of eCRS.
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