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Updated: Feb 9, 2026

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
Published on: March 10, 2017
Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria
Sara Ceballos1, Choon Kim2, Derong Ding2
1Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain.
Abstract:
The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is ≤1 μg/ml.
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