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Remote Ischemic Conditioning in Cerebral Diseases and Neurointerventional Procedures: Recent Research Progress
Geng Zhou1,2, Ming Hua Li1, Gabriel Tudor2
1Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Frontiers in Neurology
|June 6, 2018
Summary
Remote ischemic conditioning (RIC) offers a promising, non-invasive method to protect the brain from ischemia/reperfusion injury. This technique, applied remotely, has shown benefits in reducing stroke and improving outcomes in neurovascular procedures.
Area of Science:
- Neuroscience
- Cardiovascular Medicine
- Neurosurgery
Background:
- Cerebral ischemia and stroke are significant global health burdens.
- Ischemia/reperfusion (IR) injury remains a major challenge in neurointerventional procedures.
- Pharmacological neuroprotection strategies have yielded limited success.
Purpose of the Study:
- To summarize mechanisms of conditioning therapies.
- To explore the translation of conditioning from lab to neurovascular diseases.
- To outline patient care applications for conditioning.
Main Methods:
- Review of existing literature on remote ischemic conditioning (RIC).
- Analysis of neuroprotective signaling pathways involved in conditioning.
- Examination of clinical translation and application of RIC.
Main Results:
- RIC protects organs from IR injury and reduces infarct size.
- RIC mechanisms involve protein kinase B, nitric oxide, and transcriptional activators.
- Clinical studies show improved outcomes with RIC, despite protocol variations.
Conclusions:
- RIC is a simple, non-invasive, and flexible neuroprotective strategy.
- RIC has potential applications in patients undergoing neurovascular surgery or at high risk of brain injury.
- Further research and standardized protocols may enhance RIC's clinical impact.
Keywords:
acute ischemic strokeischemia/reperfusion injuryneurointerventional proceduresneuroprotectionremote ischemic conditioningMore Related Videos
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