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Updated: Feb 9, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
[Risk factors of level Ⅵ lymph node metastasis in cN0 papillary thyroid carcinoma]
1Department of Otolaryngology Head and Neck Surgery, Navy General Hospital, Center of Otolaryngology of PLA, Beijing, 100048, China.
Abstract:
Objective:To study the risk factors related to level Ⅵ lymph node metastasis in clinical N0 (cN0) papillary thyroid carcinoma (PTC). Method:A total of 107 cases with cN0 PTC treated in the same group were analyzed retrospectively. The frequency and risk factors for level Ⅵ lymph node metastasis in these patients were analyzed. Result:Level Ⅵ lymph node metastasis existed in 51.40% (55/107) cases. In univariate analysis, level Ⅵ lymph node metastasis was associated with age (χ²=9.090,P<0.01), gender (χ²=5.061,P<0.05), tumor maximum diameter (χ²=8.772,P<0.01), tumor multifocality (χ²=8.120,P<0.01), capsular invasion (χ²=4.960,P<0.05), and surrounding tissue invasion (χ²=3.858,P<0.05), but not with nodular goiter or Hashimoto's thyroiditis. Multivariate logistic analysis indicated that age,tumor maximum diameter, multifocal tumors and surrounding tissue invasion were independent risk factors for level Ⅵ lymph node metastasis. Conclusion:A high risk level Ⅵ lymph node metastasis exists in DTC with clinical N0. Prophylactic level Ⅵ neck dissection is strongly recommended in patients with PTC who are younger, tumor size more than 2 cm, multifocal tumor and surrounding tissue invasion.
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