[The impact of asthma on nasal function in patient with allergic rhinitis]

Objective:To observe the impact of lower allergic respiratory inflammation on nasal function in patient with allergic rhinitis.Method: Patients were divided into three group: allergic rhinitis group, allergic rhinitis with asthma group and control group; the nasal mucociliary transporting rate was evaluated by saccharin test; The pH of nasal mucosa extraction was evaluated by pH test paper; the nasal resistance was evaluated by nasal resistance instrument; the content of eosinophil cationic protein of nasal lavage fluid was evaluated by immunofluorescence.Result: The nasal mucociliary transporting rate was 13.40 mm/min,15.51 mm/min, and 8.03 mm/min in allergic rhinitis group, allergic rhinitis with asthma group and control group,respectively;The pH of nasal mucosa was 6.39, 6.36 and 6.67, respectively, while the pH of allergic rhinitis group and allergic rhinitis with asthma group were significantly higher than control group;the nasal resistance was 0.579 Pa/(cm3•s),0.590 Pa/(cm3•s),and 0.424 Pa/(cm3•s) in allergic rhinitis group, allergic rhinitis with asthma group and control group, respectively, and the nasal resistance of allergic rhinitis group and allergic rhinitis with asthma group were significantly higher than control group;the content of eosinophil cationic protein of nasal lavage fluid was 27.98 μg/L, 35.74 μg/L, and 4.92 μg/L, respectively.Conclusion:The recurrent attack of asthma could lower nasal mucociliary transporting rate in patient with allergic rhinitis, promote the infiltration of EOS in nasal mucosa. In conclusion asthma could play an important role in the pathogenesis of allergic rhinitis.