[Progress on the relationship between IL-35 and respiratory allergic disease]

Area of Science:

• Immunology
• Cytokine Biology
• Respiratory Medicine

Background:

• Interleukin 35 (IL-35) is a cytokine composed of IL-12P35 and Epstein-Barr virus-induced gene 3 (EBI3).
• IL-35 is essential for regulatory T cells (Tregs) and shows potential as an anti-inflammatory treatment.
• Its specific role in human respiratory allergic diseases remains unclear.

Purpose of the Study:

• To review the current research on Interleukin 35 (IL-35) in the context of human respiratory allergic diseases.
• To elucidate the function and implications of IL-35 in bronchial asthma, allergic rhinitis, and nasal polyps.

Main Methods:

• Literature review of in-vitro and mouse model studies on IL-35.
• Analysis of research progress concerning IL-35 and specific respiratory allergic conditions.

Main Results:

• In-vitro and mouse studies confirm IL-35's anti-inflammatory properties.
• Research on IL-35's direct role in human bronchial asthma, allergic rhinitis, and nasal polyps is ongoing.

Conclusions:

• IL-35 presents a potential therapeutic avenue for inflammatory conditions.
• Further investigation is required to fully understand and utilize IL-35 in managing human respiratory allergies.