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Impairment of Arterial Compliance in Cushing's Syndrome
Pier Paolo Bassareo1, Angela Maria Zedda2, Giuseppe Mercuro3
1Chief of the Section of Paediatric Cardiology, Department of Medical Sciences 'M Aresu', University of Cagliari, Cagliari, Italy.
Insights
Cushing's syndrome can cause arterial stiffness, a cardiovascular risk factor, even after treatment. Early detection of vascular changes in these patients is crucial for preventing heart disease.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Vascular Biology
Background:
- Arterial stiffness is a key indicator of cardiovascular risk in various conditions like hypertension and diabetes.
- Cushing's syndrome, a metabolic disorder, is associated with vascular alterations and increased arterial wall stiffness.
Purpose of the Study:
- To review studies evaluating arterial distensibility in patients with Cushing's syndrome.
- To highlight the importance of identifying early vascular changes in Cushing's syndrome patients.
Main Methods:
- Literature review of studies on arterial distensibility in Cushing's syndrome.
- Analysis of existing research on vascular function in affected individuals.
Main Results:
- Cushing's syndrome is linked to increased arterial stiffness.
- Elevated arterial stiffness can persist even after successful Cushing's syndrome treatment.
Conclusions:
- Arterial stiffness is a significant concern in Cushing's syndrome.
- Early detection and management of vascular alterations are vital for cardiovascular event prevention in these patients.
Abstract:
Arterial stiffness may be useful for stratifying cardiovascular risk in individuals suffering from a number of pathologies, such as hypertension, diabetes, obesity, dyslipidaemia and coronary artery disease. Cushing's syndrome is underpinned by a complex metabolic syndrome, which is potentially implicated in the onset of blood vessel alterations and the increase in arterial wall stiffness. The aim of this paper was to perform a review about the most important studies conducted in order to evaluate the arterial distensibility profile of subjects affected by Cushing's syndrome. Increased arterial stiffness may persist even after successful cure of this disease. It is therefore of fundamental importance to identify the presence of early vascular alterations in these patients, in order to commence their treatment and thus attempt to prevent the subsequent onset of adverse cardiovascular events.