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Updated: Feb 9, 2026

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Aquaporin-1 expression in fluoro-edenite-induced mesothelioma effusions: An approach by cell-block procedure

G Angelico1, A Ieni1, R Caltabiano2

  • 1Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", Unit of Pathological Anatomy, University of Messina, AOU Policlinico G. Martino, Messina, Italy.

Cytopathology : Official Journal of the British Society for Clinical Cytology
|June 7, 2018
PubMed
Abstract

Insights

High expression of Aquaporin 1 (AQP-1) in fluoro-edenite-induced malignant mesothelioma (MM) pleural effusions is detectable and offers prognostic value. This finding aids in predicting patient survival outcomes for MM.

Area of Science:

  • Oncology
  • Cell Biology
  • Environmental Health

Background:

  • Pleural malignant mesothelioma (MM) is a serious cancer.
  • Aquaporin 1 (AQP-1) water channel protein expression is a potential prognostic marker in MM.
  • Fluoro-edenite (FE) exposure is linked to increased MM risk in certain areas.

Purpose of the Study:

  • To evaluate AQP-1 expression in MM pleural effusions.
  • To determine the prognostic value of AQP-1 in FE-associated MM.
  • To assess AQP-1 detectability in cytological samples.

Main Methods:

  • Studied 25 MM cases from Biancavilla, Italy (high FE area).
  • Utilized cytological samples and cell-blocks (CB).
  • Performed immunohistochemistry for MM markers and AQP-1 on CB, defining high expression as ≥50% tumor cell membranous staining.

Main Results:

  • Median survival for all MM patients was 14 months.
  • High AQP-1 expression (≥50%) was observed in 16 cases.
  • High AQP-1 expression showed a significant association with a slightly increased overall survival (12 months vs. 7 months for low expression].

Conclusions:

  • High AQP-1 expression is detectable in cytological samples of FE-induced MM.
  • AQP-1 expression demonstrates prognostic value in these cases.
  • This finding can aid in patient outcome prediction for MM.
Keywords:
aquaporin-1cell-blockfluoro-edeniteimmunocytochemistrymalignant mesotheliomaprognosis

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