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Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
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Gastrointestinal Stromal Tumor Metastasis to the Orbit
Kelsey A Roelofs1, Shaun Medlicott2, Jan-Willem Henning3
1Department of Ophthalmology and Visual Sciences, University of Alberta, Canada.
Ophthalmic Plastic and Reconstructive Surgery
|June 8, 2018
Summary
This case report details a rare instance of gastrointestinal stromal tumor (GIST) metastasis to the orbit. The patient presented with blurry vision and proptosis, confirmed as a GIST recurrence via biopsy.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Gastrointestinal stromal tumors (GIST) are rare mesenchymal neoplasms.
- Orbital metastases from GIST are exceptionally uncommon.
- Epithelioid GISTs have distinct histopathological features.
Observation:
- A 66-year-old woman presented with unilateral blurry vision and proptosis.
- Imaging revealed an orbital mass involving the superior rectus muscle.
- Histopathology confirmed epithelioid GIST metastasis with high mitotic rate, positive for KIT (CD117) and CD34.
Findings:
- This represents the second histopathologically confirmed case of orbital GIST metastasis.
- The tumor exhibited characteristics of epithelioid GIST.
Implications:
- Highlights the importance of considering rare metastatic sites for GIST.
- Underscores the need for thorough histopathological and immunohistochemical evaluation in orbital masses.
- May inform diagnostic and treatment strategies for similar rare presentations.
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