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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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The Tongue and Taste Buds00:49

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The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
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Taste Buds and Receptors01:20

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Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
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What is Natural Selection?01:32

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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Nature and Nurture01:10

Nature and Nurture

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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Chirality in Nature02:30

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Related Experiment Video

Updated: Feb 9, 2026

Studying Orthodontic Tooth Movement in Mice
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Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds.

E E Smith1, S Angstadt2, N Monteiro2

  • 11 Program in Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School Medicine, Boston, MA, USA.

Journal of Dental Research
|June 8, 2018
PubMed
Summary
This summary is machine-generated.

Bioengineered tooth buds offer a superior alternative to dental implants for tooth replacement. These novel constructs mimic natural tooth development, showing promise for clinical applications.

Keywords:
ameloblastodontoblastodontogenesisregenerationstem celltissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Research

Background:

  • Tooth loss affects millions globally, with artificial dental implants having limitations.
  • Current tooth replacement therapies like implants lack natural tooth properties and can fail.

Purpose of the Study:

  • To develop bioengineered tooth buds as a superior alternative to dental implants.
  • To create highly cellularized constructs mimicking natural tooth bud development.

Main Methods:

  • Utilized postnatal dental cells encapsulated within a hydrogel material.
  • Constructed bioengineered tooth buds exhibiting key developmental features.
  • Implanted constructs subcutaneously into immunocompromised rats for evaluation.

Main Results:

  • Bioengineered tooth buds formed hallmark features of natural tooth buds.
  • Observed dental epithelial stem cell niche, enamel knot signaling centers, and transient amplifying cells.
  • Demonstrated mineralized dental tissue formation within the constructs.

Conclusions:

  • This study presents the first report of postnatal dental cells forming bioengineered tooth buds with natural developmental features.
  • Bioengineered tooth buds show significant promise as a clinically relevant tooth replacement therapy.