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Updated: Feb 9, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Breath of relief: apparent pulmonary nodule due to heterotopic ossification
Eric Abston1, Robert Novaco2, Stephanie Hon1
1Department of Pulmonology, Allergy, Sleep, and Critical Care Medicine Boston University School of Medicine Boston Massachusetts.
Abstract:
Extrapulmonary heterotopic ossification appears similarly to pulmonary nodules on CXR, and is in the differential for pulmonary nodules. It occurs following the bone trauma, and in early stages appears similarly to tumors. Heterotopic ossification is diagnosed by its calcification pattern via MRI or ultrasound and managed conservatively unless symptoms develop.
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