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Capsule endoscopy for patients with coeliac disease
Stefania Chetcuti Zammit1, David S Sanders1, Reena Sidhu1
1a Gastroenterology Department , Sheffield Teaching Hospitals , Sheffield , UK.
Expert Review of Gastroenterology & Hepatology
|June 12, 2018
Summary
Small bowel capsule endoscopy (SBCE) offers a comprehensive view of the entire small intestine for diagnosing coeliac disease. Further research is needed to fully define its role in patient assessment and monitoring.
Area of Science:
- Gastroenterology
- Immunology
- Medical Imaging
Background:
- Coeliac disease is an autoimmune disorder triggered by gluten, causing small bowel (SB) villous atrophy.
- Small bowel capsule endoscopy (SBCE) visualizes the entire SB mucosa, unlike histology limited to the proximal SB.
- Radiological methods do not assess villous morphology.
Purpose of the Study:
- To analyze the justified use of SBCE in coeliac disease assessment.
- To compare SBCE with histology, serology, and symptomatology.
- To review automated quantitative analysis for coeliac disease detection and future SBCE applications.
Main Methods:
- Comprehensive literature review on small bowel capsule endoscopy (SBCE) in coeliac disease.
- Comparative analysis of SBCE against established diagnostic methods (histology, serology, symptoms).
- Overview of automated quantitative analysis techniques for SBCE.
Main Results:
- SBCE provides unparalleled mucosal visualization of the entire small bowel.
- Histology is typically confined to the proximal small bowel.
- SBCE presents new diagnostic and monitoring possibilities for coeliac disease.
Conclusions:
- SBCE is a valuable tool for coeliac disease diagnosis and monitoring.
- Larger studies focusing on SBCE morphological features are required.
- Further research will refine SBCE's role in coeliac disease management.
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