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Updated: Feb 9, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
Design of minocycline-containing starch nanocapsules for topical delivery
J M Marto1, L F Gouveia1, L M D Gonçalves1
1a Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa) , Universidade de Lisboa , Lisboa , Portugal.
Abstract:
Pharmaceutical research has been focussed on developing improved delivery systems while exploring new ways of using approved excipients. The present work investigated the potential of starch nanocapsules (StNC) as a topical delivery platform for hydrophilic antimicrobial drugs using minocycline hydrochloride (MH) as a model drug. Thus, a quality by design approach was used to assess the role of different factors that affect the main pharmaceutical properties of StNC prepared using an emulsification-solvent evaporation method. Full characterisation was performed in terms of particle size, encapsulation efficiency, morphology and physical stability at 5 ± 3 °C. Results show the surfactant and lipid contents play a major role in StNC particle size distribution. The MH loading only promoted minor changes upon StNC properties. Formulations were stable without variations on physicochemical properties. All tested formulations presented a zeta-potential of +33.6 ± 6.7 mV, indicating a good physical stability and evidencing that StNC are suitable nanocarriers for topical use.
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