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Published on: May 27, 2018
Self-Synthesizing Models of Helical Proteins Based on Aromatic Disulfide Chemistry
Grzegorz Wołczański1, Marta Cal1,2, Mateusz Waliczek1
1Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383, Wrocław, Poland.
Abstract:
A new method of synthesis of peptide conjugates with aromatic moieties substituted with two sulfhydryl groups at 1,3-positions is proposed. Amphiphilic peptides derivatized in such a way under oxidative conditions spontaneously form cyclic, covalent trimers and tetramers dominated by α-helical conformations. The tendency to form tri- or tetrahelical bundles depends on sequences of the peptides and on the oxidation conditions, pH, and additives.
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