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Bidirectional relationships between sleep and amyloid-beta in the hippocampus

Julien Dufort-Gervais1, Valérie Mongrain2, Jonathan Brouillette1

  • 1Department of Pharmacology and Physiology, Montréal, Québec, Canada; Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, CIUSSS-NIM, Montréal, Québec, Canada.

Neurobiology of Learning and Memory
|June 18, 2018
PubMed
Summary

Alzheimer's disease (AD) involves amyloid-beta (Aß) buildup affecting memory and sleep. This review explores the link between hippocampal Aß pathology and sleep disturbances in AD mouse models.

Keywords:
Alzheimer’s diseaseAmyloid-beta oligomersElectroencephalographic activityMouse modelsSleep architectureSleep fragmentation

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