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Accommodation in ABO-incompatible organ transplants.

Mayara Garcia de Mattos Barbosa1, Marilia Cascalho1,2, Jeffrey L Platt1,2

  • 1Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

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|June 19, 2018
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Summary
This summary is machine-generated.

Transplant accommodation allows organs to resist immune attack, particularly in ABO-incompatible kidney transplants. This review explores mechanisms and proposes a new model for understanding this protective phenomenon.

Keywords:
ABO-incompatible transplantaccommodationblood groupblood typekidney transplantrejection

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Area of Science:

  • Transplantation immunology
  • Organ transplantation science

Background:

  • Accommodation describes a transplant's resistance to immune injury and function loss.
  • This phenomenon is most studied in ABO-incompatible kidney transplantation.
  • It involves transplants with blood group antigens functioning in recipients with antibodies against those antigens.

Purpose of the Study:

  • To critically review the mechanisms underlying transplant accommodation.
  • To propose a new working model for the kinetics of accommodation development.
  • To discuss broader implications of ABO-incompatible transplant findings.

Main Methods:

  • Literature review of accommodation in transplantation.
  • Analysis of factors influencing accommodation (antibodies, antigens, transplant response).
  • Development of a novel kinetic model for accommodation.

Main Results:

  • Accommodation is a key factor in successful ABO-incompatible kidney transplants.
  • Potential mechanisms involve changes in antibodies, antigens, or the transplant's response.
  • A new model is proposed to explain the timing of accommodation.

Conclusions:

  • Understanding accommodation is crucial for improving transplant outcomes.
  • The principles of accommodation may apply beyond ABO-incompatible transplantation.
  • Further research into accommodation mechanisms can guide future strategies.