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Published on: November 10, 2017
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Meta-analysis indicates that resistant starch lowers serum total cholesterol and low-density cholesterol
1Department of Health Toxicology and Nutrition, School of Public health, Shandong University, Jinan 250012, China.
Nutrition Research (New York, N.Y.)
|June 20, 2018
Summary
Resistant starch (RS) supplementation effectively lowers total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). Longer supplementation periods (>4 weeks) enhance these cholesterol-lowering effects.
Area of Science:
- Nutrition Science
- Dietary Interventions
- Cardiovascular Health
Background:
- Inconsistent findings exist regarding resistant starch's (RS) impact on serum cholesterol.
- Previous studies require synthesis to clarify RS's role in lipid management.
Purpose of the Study:
- To conduct a meta-analysis evaluating the effect of resistant starch (RS) on blood lipid profiles.
- To consolidate current literature on RS and its association with cholesterol and triglyceride levels.
Main Methods:
- Systematic literature search of PubMed, Embase, Scopus, and Cochrane Library up to September 2017.
- Inclusion of 14 articles (20 trials) assessing RS effects on total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol.
- Random-effects model used for pooled effect calculation and subgroup analysis.
Main Results:
- Resistant starch (RS) supplementation significantly reduced total cholesterol (TC) and LDL-C levels.
- Longer RS supplementation duration (>4 weeks) showed more pronounced reductions in TC and LDL-C.
- Higher RS dosage (>20 g/d) was associated with a lowering effect on triglyceride (TG) levels.
Conclusions:
- Resistant starch (RS) demonstrates efficacy in reducing serum TC and LDL-C.
- Optimal cholesterol-lowering benefits are observed with RS supplementation exceeding 4 weeks.
- Further research is recommended on RS types, diverse populations, and underlying mechanisms.
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