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Updated: Feb 8, 2026

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
Published on: January 21, 2021
Micro/nano acoustofluidics: materials, phenomena, design, devices, and applications
William Connacher1, Naiqing Zhang, An Huang
1Medically Advanced Devices Laboratory, Center for Medical Devices and Instrumentation, Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA 92093-0411, USA. jfriend@eng.ucsd.edu.
Acoustic actuation using sound waves offers a breakthrough for lab-on-a-chip devices, enabling precise control of fluids and particles. This technology promises to revolutionize microfluidics across various scientific fields.
Area of Science:
- Microfluidics
- Acoustics
- Materials Science
Background:
- Lab-on-a-chip devices face challenges in fluid and particle manipulation.
- Acoustic actuation presents a promising solution for microfluidic control.
Purpose of the Study:
- To provide a comprehensive review of acoustofluidics.
- To detail recent technological advances and scientific discussions in the field.
- To highlight the potential of acoustic actuation in microfluidics.
Main Methods:
- Review of piezoelectricity, piezoelectric materials, and transducers.
- Examination of acoustofluidic principles.
- Analysis of recent achievements in acoustic wave-driven fluid and particle manipulation.
- Discussion of micro/nano acoustofluidic phenomena.
Main Results:
- Acoustic actuation enables precise manipulation of fluids and particles in sessile drops and closed channels.
- Key phenomena like atomization, translation, mixing, and droplet formation are achieved.
- Recent advancements extend acoustofluidics to the nanoscale.
Conclusions:
- Acoustic actuation is poised to revolutionize lab-on-a-chip technology.
- The technology has broad applications in chemistry, biology, medicine, energy, and manufacturing.
- Further development promises novel, unimagined applications.
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10:14Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles
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