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Published on: June 26, 2020
Spatially encoded diffusion-ordered NMR spectroscopy of reaction mixtures in organic solvents
Ghanem Hamdoun1, Ludmilla Guduff, Carine van Heijenoort
1Institut de Chimie des Substances Naturelles, CNRS UPR2301, Univ. Paris Sud., Université Paris-Saclay, 91190 Gif-Sur-Yvette, France. jeannicolas.dumez@cnrs.fr.
Abstract:
Diffusion-ordered NMR spectroscopy (DOSY) is a powerful method for the analysis of mixtures. Classic DOSY methods require several minutes of acquisition, and we show here that DOSY experiments can be recorded in less than one second for the challenging case of solution mixtures in low-viscosity solvents. The proposed method relies on a spatial encoding of the diffusion dimension, for which convection-compensation and spectral-selection strategies are introduced. The method is illustrated with the analysis of a reaction mixture, and more accurate estimates of the diffusion coefficients are obtained.
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