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Cortical alterations in phobic postural vertigo - a multimodal imaging approach.
Pauline Popp1,2, Peter Zu Eulenburg1,2,3, Thomas Stephan1,2,3
1Department of Neurology Ludwig-Maximilians Universität Munich Germany.
Annals of Clinical and Translational Neurology
|June 22, 2018
Summary
Phobic postural vertigo (PPV) is linked to brain changes in areas controlling mood and cognition, not visual or vestibular systems. This neuroimaging study reveals distinct neural characteristics in PPV patients.
Area of Science:
- Neuroimaging
- Neuroscience
- Psychiatry
Background:
- Functional dizziness syndromes are common but poorly understood.
- Phobic postural vertigo (PPV) is a frequent diagnosis within this group.
- The neural underpinnings of PPV remain largely unknown.
Purpose of the Study:
- To investigate disease-specific brain alterations in patients with phobic postural vertigo (PPV).
- To analyze neuroimaging data including brain morphology, task response, and functional connectivity in PPV patients compared to controls.
Main Methods:
- Neuroimaging techniques were employed.
- 44 patients diagnosed with PPV and 44 healthy controls participated.
- Brain morphology, task-related activity, and functional connectivity were assessed.
Main Results:
- Increased gray matter volume was observed in prefrontal cortex regions and motor cortex in PPV patients.
- Morphological changes correlated with disease duration and depression scores.
- Altered brain activity and connectivity were found in networks related to emotion regulation, fear, and interoception.
Conclusions:
- PPV is associated with neural mechanisms involving mood regulation, fear generalization, interoception, and cognitive control.
- Findings support the link between PPV and excessive self-awareness and anxiety.
- The results suggest that PPV is not primarily due to aberrant visual or vestibular processing.
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