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Influence of i.v. lipid emulsion on lipoprotein subclass in preterm infants

Hiroki Suganuma1, Naho Ikeda1, Natsuki Ohkawa2

  • 1Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|June 23, 2018
PubMed

Insights

Intravenous lipid emulsions affect high-density lipoprotein (HDL) particle content in very low-birthweight infants (VLBWI). This study reveals how lipid emulsion impacts lipid metabolism in this vulnerable infant population during the early postnatal period.

Area of Science:

  • Neonatal Medicine
  • Lipid Metabolism
  • Intravenous Nutrition

Background:

  • Intravenous lipid emulsions are typically metabolized rapidly by apoprotein from high-density lipoprotein (HDL) particles.
  • Very low-birthweight infants (VLBWI) exhibit impaired lipid clearance, necessitating cautious lipid emulsion administration to prevent hyperlipidemia.

Purpose of the Study:

  • To investigate the impact of intravenous lipid emulsion on the lipoprotein subclass profile in VLBWI.
  • To assess early postnatal lipid metabolism alterations in VLBWI receiving lipid emulsions.

Main Methods:

  • Forty-six VLBWI received varying doses of lipid emulsion in early life.
  • Lipoprotein subclasses (VLDL, LDL, HDL) were analyzed for triglyceride and cholesterol content at 3 weeks postpartum.
  • Correlation between total lipid emulsion dose and lipoprotein lipid content was calculated.

Main Results:

  • No correlation was found between lipid emulsion dose and triglyceride/cholesterol in VLDL or LDL subclasses.
  • A significant negative correlation was observed between lipid emulsion dose and triglyceride content in very large, large, and medium HDL particles.
  • Cholesterol content in large and medium HDL particles also showed a significant negative correlation with the lipid emulsion dose.

Conclusions:

  • Intravenous lipid emulsion administration influences triglyceride and cholesterol levels in HDL particles of VLBWI.
  • These findings suggest that lipid emulsions can modulate lipid metabolism in VLBWI during the early neonatal period.
Abstract

Keywords:
lipid emulsionlipoprotein subclassvery low-birthweight infant

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