EFFECT OF SOLUTIONS BASED ON TRICARBONIC ACID CYCLE SUBSTRATES ON TEMPERATURE RATES IN CHILDREN DURING ANESTHESIA.

Area of Science:

• Anesthesiology
• Pediatric Surgery
• Physiology

Background:

• Maintaining intraoperative temperature homeostasis is crucial during surgery.
• Perioperative hypothermia can lead to adverse outcomes in pediatric patients.
• Current methods for temperature regulation require optimization.

Purpose of the Study:

• To evaluate the efficacy of balanced crystalloid solutions in correcting intraoperative hypothermia.
• To investigate the role of amino acids and Krebs cycle substrates in temperature regulation.
• To assess the impact of specific solutions (Mafusol, Reamberin) on temperature homeostasis.

Main Methods:

• A study involving 107 pediatric patients undergoing thoracic or abdominal surgery.
• All surgeries were conducted under total intravenous anesthesia with artificial lung ventilation.
• Infusions of 0.9% sodium chloride, Mafusol, Infezol-40, and Reamberin were administered to correct hypothermia.

Main Results:

• Solutions based on fumarate (Mafusol) and succinate (Reamberin) demonstrated a significant positive effect on temperature homeostasis.
• These solutions were effective in preventing and eliminating intraoperative hypothermia.
• The study identified specific crystalloid solutions with beneficial thermoregulatory properties.

Conclusions:

• Balanced crystalloid solutions containing Krebs cycle substrates are effective in managing intraoperative hypothermia.
• Mafusol and Reamberin show promise for widespread clinical use in pediatric surgical settings.
• These findings support the use of targeted infusions for improved temperature management during surgery.