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Genomics of Peritoneal Malignancies.
Enusha Karunasena1, Jonathan Sham2, Kevin Wyatt McMahon2
1Department of Oncology, GI Clinical Cancer Research and Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institute, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Surgical Oncology Clinics of North America
|June 25, 2018
Summary
Aggressive cancers can spread to the peritoneum, forming peritoneal metastasis. Genomic variants are key indicators of this spread and potential targets for new therapies.
Area of Science:
- Oncology
- Genetics
- Surgical Oncology
Background:
- The peritoneum protects abdominal organs but can be a site for aggressive cancer spread, known as peritoneal metastasis.
- Peritoneal malignancies often arise from epithelial-mesenchymal transition and share genetic similarities with primary tumors, alongside clone-specific aberrations.
Purpose of the Study:
- To discuss genomic variants associated with peritoneal metastasis from various cancers.
- To explore genetic and genomic variances as predictive markers for peritoneal malignancies.
Main Methods:
- Review of existing literature on genomic variants in peritoneal metastasis.
- Analysis of genetic mutations and aberrations in metastatic lesions compared to primary tumors.
Main Results:
- Genomic variants play a crucial role in the development of peritoneal metastasis.
- Metastatic lesions can exhibit unique genetic changes that facilitate their growth.
- Genetic and genomic variances show promise as predictive markers for peritoneal malignancies.
Conclusions:
- Understanding genomic variances is essential for predicting and potentially treating peritoneal metastasis.
- Targeting specific genetic aberrations may offer new therapeutic strategies for peritoneal malignancies.
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