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Updated: Feb 8, 2026
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Digital Microfluidics for Automated Proteomic Processing
Published on: November 6, 2009
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Anti-thrombotic strategies for microfluidic blood processing.
Keith H K Wong1, Jon F Edd, Shannon N Tessier
1BioMEMS Resource Center, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. mtoner@hms.harvard.edu sstott@mgh.harvard.edu.
Lab on a Chip
|June 26, 2018
Summary
This study explores how shear stress and hypothermic storage affect blood clot formation in microfluidic devices. Effective anti-thrombotic strategies were identified for blood processing applications.
Area of Science:
- Biomedical Engineering
- Hematology
- Microfluidics
Background:
- Blood coagulation is vital for hemostasis but complicates medical device blood processing.
- Platelet activation during hypothermic storage increases thrombosis risk in stored blood.
Purpose of the Study:
- Investigate shear stress and hypothermic storage effects on thrombus formation in microfluidics.
- Identify effective anti-thrombotic strategies for blood processing in medical devices.
Main Methods:
- Utilized microfluidic devices to simulate blood processing conditions.
- Assessed thrombus formation under varying shear stress and blood storage conditions.
- Tested glycoprotein IIb/IIIa inhibitors and thiol-containing antioxidants.
Main Results:
- Fresh blood thrombosis occurred at high shear, inhibited by glycoprotein IIb/IIIa inhibitors.
- Stored blood showed increased thrombosis risk, manageable with inhibitors at low shear.
- High shear in stored blood involved von Willebrand factor, requiring antioxidants for inhibition.
- Strategies validated in cyclic olefin copolymer microfluidic devices.
Conclusions:
- Anti-thrombotic strategies are effective for microfluidic blood processing.
- Findings are applicable to blood- and organ-on-a-chip technologies.
- Understanding shear and storage effects is key for safe medical device design.
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