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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Relation between lipoprotein-associated phospholipase A2 mass and incident ischemic stroke severity
Feng Zhou1, Yukai Liu1, Hongchao Shi1
1Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Summary
Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are linked to initial stroke severity. Higher Lp-PLA2 may predict severe ischemic stroke, aiding in risk stratification.
Area of Science:
- Neurology
- Biomarkers
- Cardiovascular Research
Background:
- Ischemic stroke presents with diverse clinical manifestations.
- Serum biomarkers can aid in stratifying the risk of severe stroke.
- Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a potential biomarker for stroke severity.
Purpose of the Study:
- To evaluate the association between lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and the initial severity of ischemic stroke.
- To determine if Lp-PLA2 can serve as a predictive marker for severe ischemic stroke.
Main Methods:
- Retrospective analysis of 488 first-onset ischemic stroke patients.
- Measurement of Lp-PLA2 mass and assessment of stroke severity using the National Institutes of Health Stroke Scale (NIHSS).
- Multivariate logistic regression and receiver operator curve (ROC) analysis to identify risk factors and predictive value.
Main Results:
- Patients with higher Lp-PLA2 levels exhibited greater initial stroke severity (median NIHSS 4 vs. 3, P < 0.001).
- Lp-PLA2 levels correlated with admission NIHSS (r=0.268, P < 0.001).
- Lp-PLA2 was an independent predictor of severe stroke (NIHSS ≥ 7), and its inclusion improved predictive models.
Conclusions:
- Lp-PLA2 is independently associated with the initial severity of ischemic stroke.
- Lp-PLA2 demonstrates potential as a predictive biomarker for severe stroke.
- Measuring Lp-PLA2 may enhance risk stratification for ischemic stroke patients.
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