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Mechanism Of Nephroprotection By Picrorhiza Kurroa
Afsheen Siddiqi1, Zainab Nazneen2, 1
1Department of Pharmacology, Ayub Medical College, Abbottabad, Pakistan.
Journal of Ayub Medical College, Abbottabad : JAMC
|June 26, 2018
Summary
Nimesulide can harm kidneys, but Picrorhiza kurroa shows potential as a herbal alternative. This study found Picrorhiza kurroa improved kidney function without affecting urinary PGE2 levels.
Area of Science:
- Nephrology
- Pharmacology
- Herbal Medicine
Background:
- Chemicals pose risks to kidney health, necessitating safer alternatives.
- Non-steroidal anti-inflammatory drugs like nimesulide can cause nephrotoxicity.
- Herbal remedies are being explored for anti-inflammatory and kidney-protective properties.
Purpose of the Study:
- To identify a herbal alternative with anti-inflammatory and nephroprotective effects.
- To investigate the mechanism of nephroprotection offered by the herbal alternative.
Main Methods:
- Experimental study using mice to induce nephrotoxicity with nimesulide.
- Administered Picrorhiza kurroa in two doses (250 mg/kg and 500 mg/kg) for 14 days.
- Assessed renal function and measured urinary PGE2 to evaluate protective effects.
Main Results:
- Significant improvement in serum urea and creatinine levels observed with Picrorhiza kurroa treatment.
- No significant change in urinary PGE2 levels, indicating a non-vasodilatory mechanism.
Conclusions:
- Nimesulide exhibits nephrotoxic potential.
- Picrorhiza kurroa demonstrates efficacy as a herbal anti-inflammatory and nephroprotective agent.
- The nephroprotective mechanism of Picrorhiza kurroa does not involve PGE2 modulation.
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