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Published on: January 12, 2018
Efficacy Of 17- Α-Hydroxy-Progestrone In Prevention Of Preterm Labour In High Risk Pregnant Women
Wajiha Shadab1, Shazia Riaz1, Farzana Aftab2
1Islamic International Medical College, Islamabad.
17-alpha hydroxyprogesterone effectively prevents preterm delivery in high-risk women. This study demonstrated its efficacy in reducing births before 37 weeks gestation.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Pharmacology
Background:
- Preterm delivery before 37 weeks gestation is a leading cause of infant mortality.
- Identifying effective interventions for high-risk pregnancies is crucial for improving neonatal outcomes.
Purpose of the Study:
- To evaluate the efficacy of 17-alpha hydroxyprogesterone in preventing preterm delivery in women at high risk.
- To compare the outcomes of women receiving 17-alpha hydroxyprogesterone with a control group.
Main Methods:
- A randomized controlled trial was conducted with 132 high-risk women (history of preterm delivery, <20 weeks gestation).
- Participants were randomized into two groups: intramuscular 17-alpha hydroxyprogesterone (n=66) or intramuscular Neurobion (control, n=66).
- Data was collected and statistically analyzed to compare delivery outcomes between groups.
Main Results:
- A statistically significant difference (p<0.01) was observed between the treatment and control groups.
- The group receiving 17-alpha hydroxyprogesterone showed a greater reduction in preterm deliveries.
Conclusions:
- 17-alpha hydroxyprogesterone is an effective pharmacological intervention for preventing delivery before 37 weeks gestation.
- The drug demonstrates significant efficacy in high-risk populations, potentially reducing adverse neonatal outcomes associated with prematurity.
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