Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.4K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.4K
Fixation and Sectioning01:03

Fixation and Sectioning

8.0K
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
8.0K
What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

732
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
732
Behaviorism01:28

Behaviorism

4.9K
The field of behaviorism was pioneered by figures such as Ivan Pavlov, John B. Watson, and B.F. Skinner fundamentally shifted the focus of psychology to the observable and controllable aspects of human and animal behavior. This shift marked a critical evolution in the discipline, emphasizing scientific rigor and experimental methodology.
The core premise of behaviorism is its focus on observable behavior rather than internal thoughts or feelings. This approach argues that true scientific...
4.9K
Plastic Behavior01:21

Plastic Behavior

580
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
580

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Phenotype-Driven Discovery of Pro-Revascularization Chalcone Derivatives Using Zebrafish and CAM Models.

Journal of toxicology·2026
Same author

Epidemiology and disease patterns of uveitis in Taiwan: A nationwide multicenter analysis.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Hydrogen-Bond Topology Governs Clustering-Triggered Emission in Non-Conjugated Small Molecules.

The journal of physical chemistry. B·2026
Same author

Coexistence of MOG-IgG-associated bilateral optic neuritis with psoriasis vulgaris and psoriatic arthritis in an Asian patient: a rare case report.

BMC ophthalmology·2026
Same author

A Metal-Free Phthalocyanine Additive for Defect Passivation and Processing Tolerance in High-Efficiency Perovskite Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.

Investigative ophthalmology & visual science·2025

Related Experiment Video

Updated: Feb 8, 2026

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
05:54

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

Published on: December 29, 2017

10.5K

Fixation behavior in macular dystrophy assessed by microperimetry.

Wei-Yu Chiang1, Jong-Jer Lee1, Yi-Hao Chen1

  • 1Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung City, 83301, Taiwan.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|June 28, 2018
PubMed
Summary

Patients with macular dystrophy exhibit altered fixation patterns, often utilizing preferred retinal locations (PRLs) outside atrophic areas for improved visual sensitivity. These eccentric PRLs, commonly superior, offer better mean sensitivity but less stable fixation.

Keywords:
Fixation behaviorMacular dystrophyMicroperimetryPreferred retinal locus

More Related Videos

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
09:35

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

8.2K
Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

33.9K

Related Experiment Videos

Last Updated: Feb 8, 2026

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy
05:54

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

Published on: December 29, 2017

10.5K
Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
09:35

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

8.2K
Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

33.9K

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Visual Neuroscience

Background:

  • Macular dystrophy affects central vision, leading to visual impairment.
  • Fixation behavior is crucial for visual acuity and is often disrupted in retinal diseases.
  • Understanding fixation patterns in macular dystrophy can inform management strategies.

Purpose of the Study:

  • To investigate fixation behavior in patients with macular dystrophy using microperimetry.
  • To compare fixation characteristics between macular dystrophic eyes and healthy fellow eyes.
  • To analyze the relationship between fixation location and visual function in macular dystrophy.

Main Methods:

  • Retrospective study comparing macular dystrophic eyes with normal fellow eyes (control group).
  • Microperimetry was used to assess fixation behavior, including foveal mean sensitivity (MS), fixation MS, stability, centrality, and eccentric distance.
  • Demographic and clinical data, including best-corrected visual acuity and spherical equivalent, were analyzed.

Main Results:

  • Macular dystrophy patients showed poorer visual acuity, foveal MS, fixation MS, stability, and centrality compared to controls.
  • Preferred retinal locations (PRLs) were frequently eccentric and most commonly located superiorly (48.3%) in macular dystrophy.
  • Fixation outside the atrophic lesion yielded greater MS improvement (7.41 dB) but less stable fixation compared to fixation within the lesion.

Conclusions:

  • The superior aspect of the macula is a common site for preferred retinal locations (PRLs) in macular dystrophy.
  • Utilizing PRLs outside areas of atrophy can enhance visual sensitivity in macular dystrophy.
  • Eccentric fixation distance is significantly associated with improved visual sensitivity in these patients.