RNA INTERFERENCE: NEW APPROACH TO THE TREATMENT OF ALLERGIC ASTHMA (A REVIEW)

Area of Science:

• Immunology
• Genetics
• Bioinformatics
• Molecular Biology

Background:

• Asthma is a prevalent chronic airway disease affecting all age groups, characterized by high mortality and significant impacts on quality of life and economic costs.
• The increasing incidence of asthma necessitates the identification of novel therapeutic targets and innovative treatment strategies.
• Advances in molecular immunology, genetics, and bioinformatics have identified key genes implicated in asthma pathogenesis, paving the way for targeted therapies.

Purpose of the Study:

• To review and analyze the experimental data on the application of RNA interference (RNAi) technology for asthma treatment.
• To highlight RNAi as a promising therapeutic approach for asthma, considering its efficacy and cost-effectiveness compared to other gene regulation technologies.

Main Methods:

• Review and synthesis of existing experimental studies on RNA interference in asthma models.
• Analysis of various sequence-specific gene regulation technologies, including antisense oligonucleotides (ASO), ribozymes, DNAzymes, external guide sequences (EGS), DNA decoys, and U1 adapters.
• Focus on RNA interference as the most promising technology based on efficacy and financial considerations.

Main Results:

• Identification of genes crucial to asthma pathogenesis through recent scientific advancements.
• Demonstration of RNA interference as a potent strategy for sequence-specific gene regulation.
• Comparison of RNA interference with other gene-targeting methods, highlighting its superior efficacy and cost-effectiveness.

Conclusions:

• RNA interference technology presents a highly promising avenue for developing novel and effective treatments for asthma.
• The ability of RNAi to specifically target and regulate pathogenic genes offers a new paradigm for asthma therapy.
• Further research and development in RNAi-based therapies could significantly improve asthma management and reduce its associated burden.