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Updated: Feb 8, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

Wentao Xu1, Junyang Ma1, Xiang-Ai Yuan2

  • 1State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, National Demonstration Center for Experimental Chemistry, Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.

Angewandte Chemie (International Ed. in English)
|June 29, 2018
PubMed

Keywords:
C−O bond activationcooperative catalysispolarity-matching effecttrifluoromethylthiolationumpolung

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