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Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
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[Salivary cortisol testing: preanalytic and analytic aspects].

Pierre Bastin1, Dominique Maiter2, Damien Gruson3

  • 1Département des laboratoires, Cliniques universitaires Saint-Luc et Université catholique de Louvain, Bruxelles, Belgique.

Annales De Biologie Clinique
|June 29, 2018
PubMed
Summary
This summary is machine-generated.

Salivary cortisol testing is a simple, non-invasive method gaining traction for Cushing

Keywords:
Cushingcortisolendocrinologypreanalyticsalivary

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Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Analytical Chemistry

Background:

  • Salivary cortisol assays, developed decades ago, have seen increased adoption in the last ten years.
  • The non-invasive nature and ease of repeated sampling make saliva an attractive matrix for cortisol analysis.
  • Salivary cortisol is now a primary screening test for Cushing's syndrome, as recommended by the American endocrinology society in 2008.

Purpose of the Study:

  • To review the main screening tests for Cushing's syndrome and highlight the rationale for including salivary cortisol testing.
  • To discuss salivary cortisone as a potential interferent and complementary analyte in cortisol secretion evaluation.
  • To examine pre-analytic, physiopathological, and analytical factors influencing salivary cortisol measurements.

Main Methods:

  • Review of existing literature on salivary cortisol assays and Cushing's syndrome screening.
  • Analysis of factors affecting salivary cortisol levels, including pre-analytic, physiopathological, and analytical variables.
  • Comparison of salivary cortisol testing with other established screening methods for Cushing's syndrome.

Main Results:

  • Salivary cortisol testing is recognized as a key component in Cushing's syndrome screening due to its practical advantages.
  • Salivary cortisone can interfere with cortisol measurements but may also offer additional diagnostic information.
  • Standardization of salivary cortisol assays remains a challenge, impacting comparability across different laboratories.

Conclusions:

  • Salivary cortisol assays offer a valuable, accessible tool for screening Cushing's syndrome.
  • Understanding and controlling factors influencing salivary cortisol levels are crucial for accurate diagnosis.
  • Further standardization efforts are needed to optimize the clinical utility of salivary cortisol testing.