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Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction
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[The role of microbiota in chronic pharyngitis]
A I Kryukov1, V Ya Kunel'skaya2, G B Shadrin2
1L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152; N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia, 117997.
Vestnik Otorinolaringologii
|June 29, 2018
Summary
Fungal pharyngitis affects 25% of patients with chronic pharyngeal inflammation, predominantly caused by Candida species. Diagnosis and treatment strategies for this common condition are discussed.
Area of Science:
- Otolaryngology
- Mycology
- Infectious Diseases
Background:
- Chronic inflammatory pharyngeal conditions are common.
- Fungal infections (pharyngomycosis) represent a significant portion of these cases.
- Understanding prevalence and causative agents is crucial for effective management.
Purpose of the Study:
- To outline modern diagnostic and treatment approaches for pharyngeal fungal infections.
- To analyze clinical manifestations and detection methods for pharyngomycosis.
- To report findings from patient investigations conducted between 2012 and 2016.
Main Methods:
- Retrospective analysis of 3,465 patients with chronic pharyngeal inflammation.
- Identification of mycotic lesions in the pharynx.
- Classification of pharyngitis forms (erythematous/atrophic vs. hypertrophic).
- Determination of causative fungal species, primarily Candida.
Main Results:
- 861 out of 3,465 patients (25%) had pharyngeal mycotic lesions.
- Fungal infection was more prevalent in hypertrophic pharyngitis (32.5%) than erythematous (19.5%).
- Candida species were responsible for 97-99% of fungal pharyngitis cases.
Conclusions:
- Pharyngomycosis is a common complication of chronic pharyngeal inflammation.
- Hypertrophic forms of pharyngitis show higher rates of fungal involvement.
- Effective diagnostic and therapeutic strategies are essential for managing Candida-related pharyngomycosis.
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